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Prevalence and severity of abdominal aortic calcification in incident non-diabetic hemodialysis patients

Usama A.A.Sharaf El Din., Mahmoud M. Elnokeety., Noha A. Osman., Amr M.Shaker., Ahmed M.Fayed., Mohamed T. Ali and Mohammed M. Elsebaie

Background: Vascular calcification (VC) is the most common complication in patients with chronic kidney disease (CKD). In order to evaluate the real burden of mineral bone disorders in the etio-pathogenesis of arterial calcification during the pre-dialysis course of CKD, we evaluated the prevalence and severity of abdominal aortic calcification (AAC) in non-diabetic CKD patients newly admitted to hemodialysis (HD).
Methods: 81 end stage renal disease (ESRD) Patients starting HD within one month were recruited. They underwent thorough clinical examination, laboratory assessment for serum calcium, phosphorus, intact parathyroid hormone (PTH), fibroblast growth factor (FGF23) and alkaline phosphatase and spiral computed tomography (CT) to assess AAC score.
Results: AAC was present in 64 patients (79%). There was a significant correlation between AAC score and age (r = 0.609, p <0.001), and FGF23(r = 0.800, p-value <0.001).
Conclusion: This study has confirmed that the frequency and severity of AAC are significant in incident hemodialysis patients. Serum FGF-23 level is the only biochemical parameter with a statistically significant correlation with AAC in incident hemodialysis patients.

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