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Estimation of serum triiodothyronine (t3), thyroxin (t4) and thyroid stimulating hormone (tsh) in cigarette smokers in khartoum state

Malak M.BakhitHamdan., Jasim M. Adam., Mawaheb Abdullah Sulliman., HarithHaider., Ahmed Mohamed., RehamIzzaldeenAbdallah., RanaMaaz., Mazin S. A. Mohamed and Mohamed Abdelgader

Background: Cigarette smoking has a number of effects on the thyroid gland including the development of Graves’ disease and thyroid multi-nodularity. However, the effect of smoking on thyroid function is more uncertain. This study aimed to estimate the levels of thyroid hormones in cigarette smokers
Materials and Methods: This study was designed as acase-controlon80 participants,40 of who were smokers as case and 40 were non-smokers as control in Khartoum State (2016-2017). Serum T3, T4 and TSH were measured by ELISA (Enzyme-Linked Immunosorbent Assay) (URIT-660 micro-plate reader made in China serial number 66001674 E)
Results:Were expressed as: (Mean ¬+SD) and sig-2 tailed Pearson:
Serum T3 level in smokers was (.063 ng/ml+ 0.18); in non-smokers was (1.48ng/ml + 0.26) and a p value of 0.0000001; T4 level in smokers was (2.75µg/dl + 0.67); in non-smokers was (5.79µg/dl +0.60) and a p value of 0.000000, and TSH level in smokers was (0.62 µIU/ml + 0.38); in non-smokers was (0.38µIU/ml +0.08) and p value of 0.009.
Conclusion: Serum T3 and T4 levels in Sudanese smokers was decreased when compared to the levels in non-smokers. WhereasTSH levels were similar

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