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Estimation of serum triiodothyronine (t3), thyroxin (t4) and thyroid stimulating hormone (tsh) in cigarette smokers in khartoum state

Author: 
Malak M.BakhitHamdan., Jasim M. Adam., Mawaheb Abdullah Sulliman., HarithHaider., Ahmed Mohamed., RehamIzzaldeenAbdallah., RanaMaaz., Mazin S. A. Mohamed and Mohamed Abdelgader

Background: Cigarette smoking has a number of effects on the thyroid gland including the development of Graves’ disease and thyroid multi-nodularity. However, the effect of smoking on thyroid function is more uncertain. This study aimed to estimate the levels of thyroid hormones in cigarette smokers
Materials and Methods: This study was designed as acase-controlon80 participants,40 of who were smokers as case and 40 were non-smokers as control in Khartoum State (2016-2017). Serum T3, T4 and TSH were measured by ELISA (Enzyme-Linked Immunosorbent Assay) (URIT-660 micro-plate reader made in China serial number 66001674 E)
Results:Were expressed as: (Mean ¬+SD) and sig-2 tailed Pearson:
Serum T3 level in smokers was (.063 ng/ml+ 0.18); in non-smokers was (1.48ng/ml + 0.26) and a p value of 0.0000001; T4 level in smokers was (2.75µg/dl + 0.67); in non-smokers was (5.79µg/dl +0.60) and a p value of 0.000000, and TSH level in smokers was (0.62 µIU/ml + 0.38); in non-smokers was (0.38µIU/ml +0.08) and p value of 0.009.
Conclusion: Serum T3 and T4 levels in Sudanese smokers was decreased when compared to the levels in non-smokers. WhereasTSH levels were similar

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