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Efficacy of silymarin to ameliorate the adverse effects of ochratoxin-a in laying hens

Y. Z. Eid, Hassan R. A, Nehad Eldebani and Sabria Abo El-soud

A total number of 120 Inshas, local layer hens of 28 weeks of age were randomly distributed into 4 groups with 3 replicates each (10 hens). Birds fed on the treatments were follow, (Control): fed a hen diet without any supplementation; (SL): fed the control diet supplemented with SL (1000 mg/kg feed); (OTA-diet): was fed the control diet contaminated with 1000 ppb of OTA/kg diet, and (OTA+SL): fed the OTA-diet plus SL (1000 mg/kg feed). Results showed that feeding OTA at 1 ppm reduced productive performance compared with those fed the control diet. In OTA treated groups total erythrocytes counts, leukocytes count, PCV and Hb were decreased as compared to control and SL groups. Albumin, globulin and serum total proteins in OTA treated groups were significantly lower as compared to control and SL groups. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly increased in OTA fed groups in comparison with control and SL groups. Creatinine and uric acid were increased in OTA treated groups but were almost normal in SL group. Results showed that OTA had a severe effect on liver and kidney but SL treated group had normal liver and kidneys showing its hepatoprotective effects.

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