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The effects of grape seeds extract on hyperlipidemia in rats: i. antioxidantstatus, liver enzymes, and histopathological changes

Amani A. Alrasheedi., Muneerah M. Mansour and Mohammed HE

Objectives We aimed to verify the benefits of grape seeds extract (GSE) on hyperlipidemic rats induced byhigh cholesterol diet. The efficacy of GSE was evaluated by antioxidant status, liver enzymes, and liver histological changes.

Introduction Prevalence of hyperlipidemia and lifestyle-related disorders prompted the search for non-conventional therapy.

Methods Forty male Wistar rats were divided into five equal groups as follows: group1: negative control group, group II: positive control (hyperlipidemic) groups III,IV and V (hyperlipidemic) orally given GSE in doses of 200, 400 and 600 mg/kg body weight, respectively

Discussion The results showed that oral administration of GSE extract to hyperlipidemic rats for one month significantly elevated serum levels of Aspartate Amino-transaminase (AST) and Alanine Aminotransferase (ALT) when compared to the control positive group. Antioxidant profile Catalase (CAT); Superoxide Dismutase (SOD), and Glutathione peroxidase (GSH-px) serum level were significantly increased as compared to the non-treated groups. The changes in liver histology were related to increasing concentrations of GSE.

Conclusion The study outcome suggests that GSE may help in the protection against hyperlipidemia-induced diseases, with further investigation need to be carried.

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