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Acanthamoeba keratitis

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Acanthamoeba keratitis

Acanthamoeba is a free living ubiquitous amoeba that is responsible for a small but increasing number of cases of keratitis. The infection is associated with minimal corneal trauma and soft contact lens wear. It typically presents as a unilateral central or paracentral corneal infiltrate, often with a ring shaped peripheral infiltrate. The lesion is often confused with fungal, bacterial, or herpetic keratitis.One of the most important features of the disease is severe pain, which is atypical for herpes simplex. The pathognomonic sign for acanthamoeba is radial neuritis or inflammation around the corneal nerve caused by the parasite. The most important step in prevention of acanthamoeba keratitis is effective education of patients about care of contact lens. Successful therapy hinges on early recognition and aggressive therapy with appropriate topical antiamoebic medication often in conjunction with penetrating keratoplasty.

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