Topical fisionerv® is effective in treatment of peripheral neuropathic pain

Angelo Tarullo., Antonella Tarullo., Emanuela Lacatena., Grazia Fuzio., Luigi Santacroce., Angelo M Inchingolo., Raffaele Cagiano., Francesco Inchingolo., Monica Caprio., Antonietta Clemente., Alessio D Inchingolo and Maria Tattoli

The aim of the present study was to evaluate, in Neu P management, the effectiveness of “fisionerv®”, a gel for topical use. This study, conducted in the “Rehabilitation Unit of N. Melli ‘s Hospital, Brindisi, Italy”. was a double- blind randomized controlled clinical trial, conducted over 8-week treatment on 58 outpatients affected by Neu P caused by lumbar sciatica or lumbar disk herniation and/or lumbar canal stenosis (31 subjects), or with carpal tunnel syndrome (27 subjects). Patients were randomly assigned to the following two groups : Group A: n = 29, received (fisionerv ® gel, 3 times /day) added to physiotherapy (forty minutes-daily session); Group B: n= 29 received a vehicle gel (placebo, 3 times /day) added to physiotherapy (forty minutes-daily session). Pain, burning, paraesthesiae and numbness were assessed by a visual analogue scale (VAS) at baseline and at the end of the treatment. Groups A showed a significant reduction in VAS and neuropathic symptoms after 8-treatment weeks with a significant difference between the treatments (group A: VAS mean=1.89 (0.77); group B: VAS mean= 3.79 (1.20) (p < 0.001).

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