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Modification of carcinogenesis in mice with chemically-induced tumors

Author: 
Natalia I. Ryzhova, Valentina P. Deryagina, Nadezhda A. Golubkina аnd Andrey P. Ilnitsky

Environmental pollution is an important problem of our time. Human activity leads to a significant accumulation of toxic and carcinogenic substances. Their combined effects can increase the risk for cancer. In an experiment on mice the effect application on skin benzo(a)pyrene (BP) at doses of 6 and 9 μg/mouse and sodium nitrite (SN) received by animals with water was studied at a concentration of 50 mg/l and 500 mg/l. The modifying effect of SN on carcinogenesis induced by BP was revealed, which was manifested by an increase of 2.4 (p <0.01) times in the incidence of skin tumors under the action of maximum doses of BP and SN (9  g/mouse and 500 mg/l). SN stimulated increase of 2.8-3.5 times (p <0.01) in hormone-dependent tumors (mammary gland + ovary + uterus). NS had a reinforcing effect on the increase in the multiplicity of tumors 1.4-1.6 times (p <0.05). The stimulating effect of NN on carcinogenesis is possibly caused by the increased formation of reactive oxygen and nitrogen forms, as well as inhibition of the phagocytic function of blood neutrophils.

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